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Prolongation of Midazolam Half-Life After Sustained Infusion for Status Epilepticus Neurol 54:1366-1368, Naritoku,D.K.&Sinha,S., 2000 See this aricle in Pubmed Article Abstract Midazolam clearance was examined in two patients with medically refractory convulsive status epilepticus. One patient received a constant infusion of midazolam for 68 hours and the other patient received a constant infusion of midazolam for 148 hours. In both patients the decline in level was, overall, much slower than expected. In half-lives of the terminal phase were longer than typically published (52.9 hours in Patient 1 and 20.1 hours in Patient 2). Thus, the data suggest that midazola m exhibits use dependent pharmacokinetic changes that may be important clinically in situations that require prolonged midazolam therapy.

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